Journal of Attention Disorders

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1087054707311213v1
11/5/546    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bedard, A.-C.
Right arrow Articles by Tannock, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bedard, A.-C.
Right arrow Articles by Tannock, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
This version was published on March 1, 2008
Journal of Attention Disorders, Vol. 11, No. 5, 546-557 (2008)
DOI: 10.1177/1087054707311213

Anxiety, Methylphenidate Response, and Working Memory in Children With ADHD

Anne-Claude Bedard

University of Toronto, Canada, Hospital for Sick Children, Toronto, Canada

Rosemary Tannock

University of Toronto, Canada, rosemary.tannock{at}utoronto.ca, Hospital for Sick Children, Toronto, Canada, Norwegian Academy of Science and Letters, Oslo

Objective: To investigate the effects of methylphenidate (MPH) on components of working memory (WM) in children with ADHD and determine whether MPH produces differential effects on WM in children with comorbid anxiety (ANX). Method: Participants were a clinical sample of 130 children with ADHD, aged 6 to 12 years old (32% comorbid ANX). Each child participated in an acute randomized, double-blind, placebo-controlled, crossover trial with single challenges of three MPH doses. Four WM measures were used that varied in processing demands (storage versus manipulation of information) and modality (auditory—verbal; visual—spatial). Results: MPH improved auditory—verbal manipulation but only in the non-ANX children with ADHD. It had no effect on auditory—verbal storage of information. Also, MPH improved the ability to manipulate visual—spatial information in both ADHD groups, but beneficial effects on visual—spatial storage were evident only in children without comorbid ANX. Conclusions: Findings provide insight into potential mechanisms underlying individual differences in treatment response in ADHD, which may facilitate more targeted treatments. (J. of Att. Dis. 2008; 11(5) 546-557)

Key Words: anxiety • methylphenidate • ADHD • working memory • children • randomized controlled trial


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Child NeurolHome page
L. M. Furman
Attention-Deficit Hyperactivity Disorder (ADHD): Does New Research Support Old Concepts?
J Child Neurol, July 1, 2008; 23(7): 775 - 784.
[Abstract] [PDF]