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Journal of Attention Disorders
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1087054707306109v1
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*Attention Deficit Hyperactivity Disorder
*Tourette Syndrome
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Article

Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome

Thomas J. Spencer M.D.1*, F. Randy Sallee M.D.2, Donald L. Gilbert, M.D.2, David W. Dunn M.D.3, James T. McCracken M.D.4, Barbara J. Coffey M.D.5, Cathy L. Budman M.D.6, Randall K. Ricardi D.O.7, Henrietta L. Leonard M.D.8, Albert J. Allen, M.D., Ph.D.9, Denai R. Milton, M.S.9, Peter D. Feldman, Ph.D.9, Douglas K. Kelsey, M.D., Ph.D.9, Daniel A. Geller, MBBS10, Steven L. Linder, M.D.11, Donald W. Lewis, M.D.12, Paul K. Winner, D.O.13, Roger M. Kurlan, M.D.14, and Mark Mintz, M.D.15

1 Massachusetts General Hospital
2 Cincinnati Children’s Hospital
3 Indiana University School of Medicine
4 Neuropsychiatric Institute, Los Angeles
5 New York University Child Study Center
6 North Shore University Hospital, Long Island Jewish Health System
7 Arizona Family Resource and Counseling Center
8 Rhode Island Hospital, Brown University
9 Lilly Research Laboratories
10 McLean Hospital, Harvard Medical School
11 Dallas Pediatric Neurology Associates
12 Monarch Research Associates
13 Premiere Research Institute, Palm Beach Neurology
14 University of Rochester School of Medicine and Dentistry
15 Clinical Research Center of New Jersey, The Center for Neurological and Neurodevelopmental Health

* To whom correspondence should be addressed. E-mail: tspencer{at}partners.org.


  Abstract
Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2007; X(X) xx-xx)

First published on October 12, 2007, doi:10.1177/1087054707306109

Journal of Attention Disorders 2008;11:470.

A more recent version of this article appeared on January 1, 2008

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