Injury Among Stimulant-Treated Youth With ADHD
Steven C. Marcus Ph.D.1,
George J. Wan Ph.D.2,
Huabin F. Zhang M.D.2,
and
Mark Olfson M.D.3*
1 University of Pennsylvania School of Social Policy & Practice
2 Ortho-McNeil Janssen Scientific Affairs, LLC
3 Columbia University
* To whom correspondence should be addressed. E-mail: mo49{at}columbia.edu.
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Abstract |
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Objective: To assess risk factors for injury among children and adolescents treated with stimulants for ADHD. Method: An analysis was performed of pharmacy and service claims data from 2000-2003 California Medicaid (Medi-Cal) focusing on children and adolescents ages 6 to 17 years who initiated stimulant therapy for ADHD. Bivariate and multivariate analyses were performed to examine associations of demographic and clinical characteristics with injury. Results: In a Cox proportional hazard model that controlled for background patient characteristics, patients ages 13 to 17 years, male gender, prescription of anxiolytic/hypnotic medications, and diagnosis of a mood disorder were each independently associated with increased risk of injury, whereas African American ancestry and other minority racial/ethnic ancestry were associated with lower risk. Youth with high stimulant medication possession ratios (MPR) had a nonsignificantly lower risk of injury as compared to those with a low stimulant MPR. Conclusion: These findings reveal several patient characteristics that may be associated with increased risk of injury among children and adolescents treated for ADHD. (J. of Att. Dis. XXXX; XX(X) xx-xx)
