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Journal of Attention Disorders, Vol. 8, No. 4, 153-159 (2005)
DOI: 10.1177/1087054705278797

Investigator Ratings of ADHD Symptoms During a Randomized, Placebo-Controlled Trial of Atomoxetine: A Comparison of Parents and Teachers as Informants

Bradley N. Bohnstedt

William G. Kronenberger

David W. Dunn

Ann L. Giauque

Elisabeth A. Wood

Mary E. Rembusch

Deborah Lafata

Indiana University School of Medicine

This study compared investigator ratings of ADHD symptoms based on interviews with parents and teachers during a doubleblind, placebo-controlled study of atomoxetine. Investigators completed the ADHD Rating Scale: Investigator (ADHDRS-I) based on separate semistructured interviews with the primary caretaker and teacher of the participant. Interviews were conducted at Visits 2 to 7 during a double-blind treatment protocol comparing atomoxetine (N= 10) and placebo (N= 6). Both parent and teacher-based ratings were sensitive to change in ADHD symptoms with atomoxetine treatment. Parent-based assessment differentiated significantly between treatment with atomoxetine and placebo, whereas teacher-based assessment was less sensitive to change. Parents and teachers showed good agreement on change in ADHDRS-I scores. Investigator ratings based on parent- and teacher-report were sensitive to change in symptoms of ADHD during treatment with atomoxetine. Despite good agreement between parent- and teacher-based ratings of symptom change, parent-based ADHD symptom ratings are more sensitive to symptom change.

Key Words: atomoxetine • ADHD • attention • hyperactivity • assessment


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