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Journal of Attention Disorders, Vol. 8, No. 2, 37-43 (2004)
DOI: 10.1177/108705470400800201

The acute effect of methylphenidate in Brazilian male children and adolescents with ADHD: A randomized clinical trial

C. M. Szobot

Federal University of Rio Grande do Sul, Brazil

C. Ketzer

Federal University of Rio Grande do Sul, Brazil

M. A. Parente

Federal University of Rio Grande do Sul, Brazil

J. Biederman

Harvard Medical School

L. A. Rohde

Federal University of Rio Grande do Sul, Brazil

Objective: To evaluate the acute efficacy of methylphenidate (MPH) in Brazilian male children and adolescents with ADHD.

Method: In a 4-day, double-blind, placebo-controlled, randomized, fix dose escalating, parallel-group trial, 36 ADHD children and adolescents were allocated to two groups: MPH (n = 19) and placebo (n = 17). Participants were evaluated pre- and posttreatment using the 10-item Conners Abbreviated Rating Scale (ABRS), the Children’s Global Assessment Scale (CGAS), and a simplified version of the Continuous Performance Test (CPT).

Results: The MPH group had a significantly greater decrease in ABRS scores and a significantly higher increase in CGAS scores than the placebo group (p < 0.01). The MPH group showed also a significantly higher proportion of patients with a robust improvement (decrement of at least 50% in the ABRS score after the intervention) than the placebo group (p < 0.01). The MPH effect size for the ABRS was 1.05 (95% CI = 0.73-1.37).

Conclusion: Our results extend the efficacy of MPH on the ADHD core symptoms extensively demonstrated in clinical trials with samples from some developed countries to a sample from a developing country where a diverse culture may modulate the clinical presentation of the disorder.


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