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Towards defining a meaningful anxiety phenotype for research in ADHD children

J. Biederman

Pediatric Psychopharmacology Unit (ACC 725), Massachusetts General Hospital, Fruit Street, Boston, MA 02114 (phone 617-726-1731; fax 617-724-1540).

E. Mick

S. V. Faraone

Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA.

Objective: To combine anxiety diagnoses empirically into a meaningful definition of a comorbid anxiety syndrome in ADHD children.

Methods: The prevalence of all DSM-111-R anxiety disorders was examined in our ADHD sample (N =237) and a Receiver Operating Characteristic (ROC) analysis was conducted to combine the information optimally from these many disorders into a single anxiety phenotype.

Results: We found that two or more anxiety disorders correctly identified a large number of ADHD children as anxious (SN=0.75) while maintaining a reasonable false positive rate (Sp=0.67). In contrast, the criterion of three or more anxiety disorders correctly identified only half the sample and the criterion of one or more anxiety disorders had a much higher false positive rate. The necessary data are also presented for those that may wish to use a definition other than 2 or more anxiety disorders.

Conclusion: These findings suggest that using 2 or more anxiety disorders may offer a useful approach to defining comorbid anxiety in ADHD youth.

Journal of Attention Disorders, Vol. 3, No. 4, 192-199 (2000)
DOI: 10.1177/108705470000300402


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