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Effects of Once-Daily Oral and Transdermal Methylphenidate on Sleep Behavior of Children With ADHD

SUNY Upstate Medical University, faraones{at}upstate.edu

Stephen J. Glatt

SUNY Upstate Medical University

Oscar G. Bukstein

University of Pittsburgh

Frank A. Lopez

Children's Developmental Center, Winter Park, FL

L. Eugene Arnold

Ohio State University

Robert L. Findling

University Hospital Case Medical Center, Cleveland

Objective: Methylphenidate is a leading first-line treatment for ADHD (AD/HD). This stimulant has long been suspected to adversely affect sleeping patterns of treated individuals, especially children. There are few studies on the effects of recently developed longer-acting methylphenidate treatments, such as once-daily oral or transdermal formulations, on sleep. Method: The authors examined eight indices of sleep behavior among children treated with either of these two methylphenidate preparations or placebo in a randomized, double-blind, multicenter, parallel-group study. Results: The main predictor of sleep problems was baseline numbers or severity of preexisting sleep problems, whereas the different treatments and placebo varied little in their propensity to elicit such problems. There was no significant relationship between dosage and severity or frequency of sleep problems. Conclusion: The authors found little evidence that methylphenidate treatment (at least in sustained-release forms) was a significant cause of sleep problems in treated children who were carefully titrated to an optimal dose. (J. of Att. Dis. 2009; 12(4) 308-315)

Key Words: ADHD • AD/HD • children's sleep habits questionnaire • ordinal logistic regression • Poisson regression • randomized controlled trial

This version was published on January 1, 2009

Journal of Attention Disorders, Vol. 12, No. 4, 308-315 (2009)
DOI: 10.1177/1087054708314844


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