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Journal of Attention Disorders
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A Pilot Study of the Effects of Atomoxetine on Driving Performance in Adults With ADHD

Russell A. Barkley

Medical University of South Carolina

Deborah L. Anderson

Medical University of South Carolina

Markus Kruesi

Medical University of South Carolina

Objective: There is a high risk of vehicular crashes, traffic citations, and poorer driving performance in adults with ADHD. This pilot study examines the value of a new nonstimulant (atomoxetine) for improving the driving performance of adults with ADHD.

Method: Atomoxetine (1.2 mg/kg daily for 3 weeks) and a placebo are studied on 18 adults with ADHD (M age = 37 years) using ratings of ADHD symptoms, impairment, and safe driving behavior; a virtual reality driving simulator; and ratings of simulator performance.

Results: Atomoxetine improves self-ratings of ADHD symptoms, impairments, safe driving behavior, and simulator driving performance. No effects of atomoxetine are evident on others’ ratings of driving behavior or on the simulator. Practice effects on the simulator may have obscured those drug effects.

Conclusion: The authors find a mixed pattern of results such that atomoxetine warrants further study for its effects on driving in this high-risk population.

Key Words: ADHD • atomoxetine • driving

Journal of Attention Disorders, Vol. 10, No. 3, 306-316 (2007)
DOI: 10.1177/1087054706292122
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This article has been cited by other articles:


Home page
 J Atten DisordHome page
G. G. Kay, M. A. Michaels, and B. Pakull
Simulated Driving Changes in Young Adults With ADHD Receiving Mixed Amphetamine Salts Extended Release and Atomoxetine
J Atten Disord, January 1, 2009; 12(4): 316 - 329.
[Abstract] [PDF]


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